|
Director of Biomedical Statistics & Methodology, Neuropsychiatric Research Institute Clinical Associate Professor, Department of Neuroscience, University of North Dakota School of Medicine Professor (Adjunct), Department of Psychology, North Dakota State University.
B.A., University of Minnesota, Psychology, 1975
Ph.D., University of Nevada, Social Psychology, 1989
Research Interests:
(1) Pharmacotherapies in the treatment of cocaine abuse, (2) Statistical applications in psychiatric research, (3) Treatment outcome research in eating disorders
Summary of Research:
The intermittent exposure of rats to cocaine over several weeks has been shown to produce kindling, a pattern of neuronal facilitation in the brain. Cocaine-induced kindling has been linked to hyperactivity, stereotypic behaviors, and to seizures. A number of anticonvulsant medications, including carbamazepine, phenytoin, and valproate, have been shown to block the development of kindling in animals. It has been speculated that in humans, cocaine-induced kindling may be experienced as intense craving. Anticonvulsant medications given to cocaine abusers may block the development of kindling, thereby eliminating or substantially reducing the craving associated with prolonged cocaine abuse. A number of open-label and double-blind studies are being conducted to examine the efficacy of these anticonvulsants in the treatment of cocaine abuse.
Selected Publications(from over 90):
1. Wonderlich, S.A.,Crosby, R.D., Mitchell, J.E., Thompson, K.M., Smyth, J., Redlin, J. & Jones-Paxton, M. Sexual trauma and personality disturbance: developmental vulnerability and addictive effects. Journal of Personality Disorders, 2001, 15(6), 496-504.
2. Wonderlich, S.A., Crosby, R.D., Mitchell, J.E., Thompson, K.M., Redlin, J., Demuth, G., Smyth, J. & Haseltine, B. Eating disturbance and sexual trauma in childhood and adulthood. International Journal of Eating Disorders, 2001, 30(4), 401-412.
3. Gosnell, B., Mitchell, J.E., Lancaster, K., Burgard, M.A., Wonderlich, S.A. & Crosby, R.D. Food presentation and energy intake in feeding laboratory study of subjects with binge eating disorder. International Journal of Eating Disorders, 2001, 30(4), 441-446.
4. Kolotkin, R.L., Crosby, R.D., WIlliams, G.R., Hartley, G.G. & Nicol, S. Relationship between health-related quality of life and weight loss. Obesity Research, 2001, 9(9), 564-571.
5. Smyth, J., Wonderlich, S.A., Crosby, R.D., Miltenberger, R.,Mitchell, J. & Rorty, M. The use of ecological momentary assessment approaches in eating disorder research. International Journal of Eating Disorders, 2001, 30, 83-95.
6. Berg, M.L., Crosby, R.D., Wonderlich, S.A. & Hawley, D. The relationship of temperament and perceptions of nonshared environemnt in bulimia nervosa. International Journal of Eating Disorders, 2000, 28(2), 148-154.
7. Wolff, G.E., Crosby, R.D., Roberts, J.A., & Wittrock, D.A. Differences in daily stress, mood, coping and eating behavior in binge eating and non-binge eating college women. Addictive Behaviors, 2000, 25(2), 205-216.
8. Thompson, K., Wonderlich, S.A., Crosby, R.D. & Mitchell, J.E. The neglected link between disordered eating and aggressive behavior. Journal of the American Academy of Child and Adolescent Psychiatry, 1999, 38(10), 1277-84.
9. Lee, Y.H., Abbott, D.W., Mitchell, J.E., Crosby, R.D., Monson, N. & Burgard, M. Eating Disorders and psychiatric disorder in the first-degree relatives of probands with binge eating disorder. International Journal of Eating Disorders, 1999, 26(3), 322-332.
10. Abbott, D.W., de Zwaan, M., Mussell, M.P., Raymond, N.C., Seim, H.C.,Crow, S.D., Crosby, R.D. & Mitchell, J.E. Onset of binge eating before dieting in overweight subjects: Implications for etiology, associated features, and treatment. Journal of Psychosomatic Research, 1998, 44, 367-374.
11. Pitts, B.G., Crosby, R.D., Laufenberg, S. & Monson, N. Weight loss outcomes of patients treated with fenfluramine-phentermine in primary care settings. Nutrition and Clinical Practice, 1998,13(5),241-250.
12. Halikas, J.A., Crosby, R.D., Pearson, V.L., Graves, N.M. A randomized double–blind study of carbamazepine in the treatment of cocaine abuse. Clinical Pharmacology & Therapeutics, 1997, 62(1), 89-105.
13. Pomeroy, C., Mitchell, J., Eckert, E., Raymond, N., Crosby, R.D. & Dalmasso, A. Effect of body weight and caloric restriction on serum complement proteins, including Factor D/Adipsin: Studies in anorexia nervosa and obesity. Clinical and Experimental Immunology, 1997, 108, 507-515.
14. Crosby, R.D., Pearson, V.L., Eller, C., Winegarden, T. & Graves, N.L. Phenytoin in the treatment of cocaine abuse: a double blind study. Clinical Pharmacology and Therapeutics, 1996, 59(4), 458-468.
15. Eckert, E.D., Halmi, K.A., Marchi, P., Grove, W. & Crosby, R.D. Ten year follow-up of anorexia nervosa: Clinical course and outcome. Psychological Medicine, 1995, 25(1); 143-156.
16. Hatsukami, D., Pentel, P., Glass, J., Nelson, R., Brauer, L.H., Crosby, R.D. & Hanson, K. Methodological issues in the administration of multiple doses of smoked cocaine-base in humans. Pharmacology Biochemistry and Behavior, 1994, 47(3), 531-540.
17. Halikas, J.A., Crosby, R.D., Pearson, V.L., Nugent, S.M. & Carlson, G.A. Psychiatric comorbidity in treatment-seeking cocaine abusers. American Journal on Addictions, 1994, 3(1), 1-11.
18. Mitchell, J.E., Pyle, R.L., Eckert, E.D., Pomeroy, C., Zollman, M., Crosby, R.D., Seim, H. & Zimmerman, R. Cognitive behavioral group psychotherapy of bulimia nervosa: Importance of logistical variables. International Journal of Eating Disorders, 1993, 14(3), 277-287.
19. Crosby, R.D., Mitchell, J.E., Raymond, N., Specker, S. & Nugent, S.M. Survival analysis of response to group psychotherapy in bulimia nervosa. International Journal of Eating Disorders, 1993, 13(4), 359-368.
20. Halikas, J.A. & Crosby, R.D. Measuring outcome in the treatment of cocaine abuse: The Drug Impairment Rating Scale for Cocaine. Journal of Addictive Diseases, 1992, 11(2), 121-138.
21. Crosby, R.D., Halikas, J.A. & Bowers, L.D. Quantitative cocaine urine testing in clinical research settings. Annals of Clinical Psychiatry, 1991, 3(3), 243-249.
22. Halikas, J.A., Crosby, R.D., Carlson, G.A., Crea, F., Graves, N.M. & Bowers, L.D. Cocaine reduction in unmotivated crack users using carbamazepine versus placebo in a short-term crossover design. Clinical Psychopharmacology and Therapeutics, 1991, 50(1), 81-95.
23. Crosby, R.D., Halikas, J.A. & Carlson, G.A. Pharmacotherapeutic interventions for cocaine abuse: Present practices and future directions. Journal of Addictive Diseases, 1991, 10(4), 13-29.
|
|
